Remarkably stable (Me3Al)2•DABCO and stereoselective nickel-catalyzed AlR3 (R = Me, Et) additions to aldehydes

被引：106

作者：

Biswas, K ^{[1
]}

Prieto, O ^{[1
]}

Goldsmith, PJ ^{[1
]}

Woodward, S ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 15期

关键词：

aluminum; asymmetric catalysis; Lewis bases; nickel; phosphoramidites;

D O I：

10.1002/anie.200462569

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Weigh it out in air! The DABAL reagent (Me3Al)2·(DABCO) (DABCO = 1,4-diazabicyclo[2.2.2] octane) can be easily handled under normal laboratory conditions. Furthermore, chiral secondary alcohols can be efficiently prepared from prochiral aldehydes (see scheme; TOF = turnover frequency) by using either DABAL or AIR3 reagents (R = Me, Et). Thus, DABAL can be used as an efficient, convenient alternative to the Schumann-Blum reagent. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2232 / 2234

页数：3

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