High prevalence of MMTV-like env gene sequences in gestational breast cancer

被引：48

作者：

Wang, Y

Melana, SM

Baker, B

Bleiweiss, I

Fernandez-Cobo, M

Mandeli, JF

Holland, JF

Pogo, BGT

机构：

[1] Mt Sinai Sch Med, Dept Med, Div Hematol Oncol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Biomath Sci, New York, NY 10029 USA

[4] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

来源：

MEDICAL ONCOLOGY | 2003年 / 20卷 / 03期

关键词：

gestational breast cancer; MMTV sequences;

D O I：

10.1385/MO:20:3:233

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-Iike sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-Iike sequences were also associated with its adverse outcome. Whereas 30-38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-Iike LTR may play a role in promoting cell growth, as they do in the mouse system.

引用

页码：233 / 236

页数：4

共 23 条

[1] MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways [J].