Interleukin-1

被引：192

作者：

Stylianou, E ^{[1
]}

Saklatvala, J

机构：

[1] Univ Nottingham Hosp, Queens Med Ctr, Sch Med & Surg Sci, Nottingham NG7 2UH, England

[2] Univ Nottingham Hosp, Queens Med Ctr, Inst Cell Signalling, Nottingham NG7 2UH, England

[3] Charing Cross Hosp, Kennedy Inst, London, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1998年 / 30卷 / 10期

关键词：

interleukin; 1; MAP kinases; signalling; NF kappa B;

D O I：

10.1016/S1357-2725(98)00081-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades. These modulate a number of transcription factors including NF kappa B, AP1 and CREB each of which regulate a plethora of immediate early genes central to the inflammatory response. Phase I clinical trials of the soluble type I receptor and IRAP indicate that these have potential anti-inflammatory effects. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1075 / 1079

页数：5

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