Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution and effect of food

被引:27
作者
Abdel-Rahman, SM
Kearns, GL
机构
[1] Childrens Mercy Hosp, Sect Pediat Clin Pharmacol & Expt Therapeut, Kansas City, MO 64108 USA
[2] Univ Missouri, Dept Pediat, Kansas City, MO 64110 USA
[3] Univ Missouri, Dept Pharm Practice, Kansas City, MO 64110 USA
[4] Univ Missouri, Dept Pharmacol, Kansas City, MO 64110 USA
关键词
D O I
10.1128/AAC.42.10.2706
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Pleconaril is an orally active broad-spectrum antipicornaviral agent which demonstrates excellent penetration into the central nervous system, liver, and nasal epithelium. We report the results of a randomized two-way crossover study designed to characterize the disposition of a single dose (200 mg) of pleconaril oral solution in fed and fasting humans, Twelve healthy adult subjects (18.7 to 39 years of age) participated in this study. Each subject received a single 200-mg dose of pleconaril oral solution, both coadministered with a standard English breakfast and following a 10-h predose fast. There was a minimum 7-day washout period between pleconaril doses. Repeated blood samples (n = 10) were obtained over 24 h postdose, and the pleconaril level in plasma was quantified by gas chromatography. Plasma concentration-versus-time data were curve fitted for each subject by using a nonlinear weighted least-squares algorithm, and pharmacokinetic parameters were determined from the polyexponential estimates. Pleconaril disposition was best characterized by a one-compartment open model with first-order absorption, The apparent bioavailability of pleconaril oral solution was significantly increased with the administration of food. The area under the concentration-time curve and maximum concentration of pleconaril in plasma achieved following the standard English breakfast (i.e., 9.08 +/- 3.23 mg/liter.h and 1.14 +/- 0.58 mg/liter, respectively) were 2.2- and 2.5-fold higher, respectively than those achieved in the fasting state (i.e., 4.08 +/- 2.74 mg/liter.h and 0.46 +/- 0.30 mg/liter, respectively). Mean plasma pleconaril concentrations 12 h after a single 2000-mg oral dose (fed, 0.25 +/- 0.2 mg/liter; fasting, 0.11 +/- 0.10 mg/liter) in healthy adults remained greater than that required to inhibit more than 90% of the enteroviruses in cell culture (i.e,, 0.07 mg/liter). To enhance the oral bioavailability of pleconaril, coadministration with a fat-containing meal is recommended.
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页码:2706 / 2709
页数:4
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