Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa

被引：97

作者：

Aubert, D

Poirel, L

Chevalier, J

Leotard, S

Pages, JM

Nordmann, P

机构：

[1] Assistance Publ Hop Paris, Hop Bicetre, Fac Med, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Fac Med Marseille, INSERM, CJF96 06, F-13385 Marseille, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期

关键词：

D O I：

10.1128/AAC.45.6.1615-1620.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudomonas aeruginosa clinical isolate SOF-1 was resistant to cefepime and susceptible to ceftazidime. This resistance phenotype was explained by the expression of OXA-31, which shared 98% amino acid identity with a class D beta -lactamase, OXA-1. The oxa-31 gene was located on a ca. 300-kb nonconjugative plasmid and on a class 1 integron, No additional efflux mechanism for cefepime was detected in P. aeruginosa SOF-1, Resistance to cefepime and susceptibility to ceftazidime in P. aeruginosa were conferred by OXA-1 as well.

引用

页码：1615 / 1620

页数：6

共 34 条

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