Preparation of zinc organometallics derived from nucleosides and nucleic acid bases and Pd(0) catalyzed coupling with aryl iodides

被引：47

作者：

Stevenson, TM

Prasad, ASB

Citineni, JR

Knochel, P

机构：

[1] UNIV MARBURG,FACHBEREICH CHEM,D-35032 MARBURG,GERMANY

[2] DUPONT CO INC,AGR PROD,STINE HASKELL LABS,NEWARK,DE 19714

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 46期

关键词：

D O I：

10.1016/0040-4039(96)01934-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Iodouracil and 6-iodopurine derivatives readily insert zinc dust (25 degrees C or 70 degrees C) in THF or DMAC affording zincated nucleic acid base derivatives which undergo efficient palladium catalyzed cross-coupling reactions with aryl iodides in good yields. This reaction sequence has been extended to two nucleosides (a purine and an uridine derivative). Copyright (C) 1996 Elsevier Science Ltd

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页码：8375 / 8378

页数：4

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