Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor

被引:253
作者
Trachtenberg, JT
Thompson, WJ
机构
[1] Department of Zoology, The University of Texas, Austin
关键词
D O I
10.1038/379174a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
DENERVATED adult mammalian muscle fibres are reinnervated by regenerating axons and, in the case of partially denervated muscles, by sprouts extended from remaining, intact axons(1,3). Recent experiments suggest that Schwann cells (SCs) regulate these events, inducing and guiding axonal outgrowth through the processes they extend(4,5). In contrast to adults, reinnervation of denervated neonatal muscles is deficient and axonal sprouting is absent(6-9). In light of the proposed roles for SCs in these processes, we examined whether SCs in neonatal muscles exhibit altered responses to denervation. We report here that neonatal denervation leads to the rapid, apoptotic death of SCs at rat neuromuscular junctions. Injection of glial growth factor, a member of the neuregulin family of trophic factors present in developing sensory and motor neurons(10), prevents this apoptosis in vivo. These results provide further evidence for the importance of SCs in regulating nerve grow,vth and suggest that axon-Schwann cell trophic interactions play a role in the normal development of the neuromuscular system.
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页码:174 / 177
页数:4
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