Bariatric surgery: a cure for diabetes?

被引：22

作者：

Varela, J. Esteban ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Sect Minimally Invas Surg, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | 2011年 / 14卷 / 04期

关键词：

bariatric surgery; glucose homeostasis; insulin resistance; beta cell function; obesity; type; 2; diabetes; pancreas burnout; Y GASTRIC BYPASS; CARDIOVASCULAR RISK-FACTORS; DUODENAL-JEJUNAL BYPASS; BETA-CELL FUNCTION; BODY-MASS INDEX; SLEEVE GASTRECTOMY; HYPERINSULINEMIC HYPOGLYCEMIA; INSULIN SENSITIVITY; METABOLIC SYNDROME; BMI LESS-THAN-35;

D O I：

10.1097/MCO.0b013e3283468e50

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review To review the basic mechanisms of caloric intake reduction of bariatric surgery and its clinical and metabolic outcomes. To describe novel bariatric procedures, their effects on glucose homeostasis and insulin sensitivity and to explain the proposed mechanisms for type 2 diabetes mellitus (T2DM) resolution. Recent findings The effects of surgically induced weight loss on T2DM have elucidated in part the role of proximal and distal gastrointestinal bypass on insulin sensitivity. A dual mechanism for improvement in glucose homeostasis after bariatric surgery has been proposed that appears to be weight loss independent. Summary Bariatric surgery is the most effective therapy for obesity and obesity-related comorbidities today that provide high rates of resolution of T2DM with improvements in insulin resistance and beta-cell function. Novel bariatric procedures offer a unique opportunity to understand the pathophysiology of T2DM and to identify potential pharmacologic targets for effective T2DM treatments and a potential cure.

引用

页码：396 / 401

页数：6

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