Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocarnpal slices

被引：28

作者：

Colgin, LL

Jia, YS

Sabatier, JM

Lynch, G

机构：

[1] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92612 USA

[2] Harbor UCLA Med Ctr, Dept Obstet & Gynecol, Torrance, CA 90509 USA

[3] CNRS, FRE, Lab Ingn Prot, Marseille, France

来源：

NEUROSCIENCE LETTERS | 2005年 / 385卷 / 01期

关键词：

sharp waves; ripples; NMDA receptors; APV; SK2; channels; calcium-activated potassium channels;

D O I：

10.1016/j.neulet.2005.05.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An in vitro model of sharp waves (SPWs) and ripples was used to investigate the involvement of NMDA receptors in SPW/ripple production. Intracellular recordings from CA3 pyramidal cells confirmed that SPWs are composed of primarily excitatory currents. Unexpectedly, NMDA receptor antagonists greatly increased the size of SPWs and ripples. This effect may have involved decreased calcium influx through NMDA receptors and a subsequent reduction in the activation of SK2 calcium-activated potassium channels. The results support the claim that activation of NMDA receptors can serve to dampen the excitation of SPWs. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：46 / 51

页数：6

共 42 条

[1] Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents [J].