Cerebral acetylcholine esterase activity in mild cognitive impairment

被引：49

作者：

Herholz, K ^{[1
]}

Weisenbach, S

Kalbe, E

Diederich, NJ

Heiss, WD

机构：

[1] Univ Cologne, Dept Neurol, Cologne, Germany

[2] Ctr Hosp, Luxembourg, Luxembourg

[3] Max Planck Inst Neurol Res, Cologne, Germany

来源：

NEUROREPORT | 2005年 / 16卷 / 13期

关键词：

acetylcholine esterase; Alzheimer's disease; longitudinal study; mild cognitive impairment (MCI); positron emission tomography;

D O I：

10.1097/01.wnr.0000177007.21732.7b

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mild cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment.

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收藏

页码：1431 / 1434

页数：4

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