Mechanisms and functional implications of adult neurogenesis

被引：2524

作者：

Zhao, Chunmei ^{[1
]}

Deng, Wei ^{[1
]}

Gage, Fred H. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

CELL | 2008年 / 132卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NEURAL STEM-CELLS; NEWLY GENERATED NEURONS; ENHANCED SYNAPTIC PLASTICITY; HIPPOCAMPAL NEUROGENESIS; OLFACTORY-BULB; DENTATE GYRUS; GRANULE CELLS; GROWTH-FACTOR; SUBVENTRICULAR ZONE; LEARNING INCREASES;

D O I：

10.1016/j.cell.2008.01.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. In this review, we discuss the factors that regulate proliferation and fate determination of adult neural stem cells and describe recent studies concerning the integration of newborn neurons into the existing neural circuitry. We further address the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

引用

页码：645 / 660

页数：16

共 113 条

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