Total enantioselective synthesis of (-)-cytisine

被引：52

作者：

Danieli, B

Lesma, G

Passarella, D

Sacchetti, A

Silvani, A

Virdis, A

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] Univ Milan, CISI, I-20133 Milan, Italy

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1021/ol0361507

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total enantiosynthesis of the biologically active alkaloid (-)-cytisine is reported, featuring a ruthenium-catalyzed RCM reaction as the key step. The approach relies on readily available cis-piperidine-3,5-dimethanol monoacetate as the chiral building block, and it is suited for achieving the target compound in both enantiomeric forms.

引用

页码：493 / 496

页数：4

共 30 条

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