X chromosome evidence for ancient human histories

被引:179
作者
Harris, EE [1 ]
Hey, J [1 ]
机构
[1] Rutgers State Univ, Dept Genet, Nelson Biol Labs, Piscataway, NJ 08854 USA
关键词
D O I
10.1073/pnas.96.6.3320
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Diverse African and non-African samples of the X-linked PDHA1 (pyruvate dehydrogenase E1 alpha subunit) locus revealed a fixed DNA sequence difference between the two sample groups. The age of onset of population subdivision appears to be about 200 thousand years ago, This predates the earliest modern human fossils, suggesting the transformation to modern humans occurred in a subdivided population. The base of the PDHA1 gene tree is relatively ancient, with an estimated age of 1.86 million years, a late Pliocene time associated with early species of Homo. PDHA1 revealed very low variation among non-Africans, but in other respects the data are consistent with reports from other S-linked and autosomal haplotype data sets. Like these other genes, but in conflict with microsatellite and mitochondrial data, PDHA1 does not show evidence of human population expansion.
引用
收藏
页码:3320 / 3324
页数:5
相关论文
共 45 条
  • [1] [Anonymous], 1998, COMMUN STAT STOCH MO, DOI [DOI 10.1080/15326349808807471, 10.1080/15326349808807471]
  • [2] BRAUER G, 1989, HUMAN REVOLUTION, P123
  • [3] MITOCHONDRIAL-DNA AND HUMAN-EVOLUTION
    CANN, RL
    STONEKING, M
    WILSON, AC
    [J]. NATURE, 1987, 325 (6099) : 31 - 36
  • [4] Cavalli-Sforza L.L., 1994, The history and geography of human genes, V1st ed.
  • [5] Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
    Clark, AG
    Weiss, KM
    Nickerson, DA
    Taylor, SL
    Buchanan, A
    Stengård, J
    Salomaa, V
    Vartiainen, E
    Perola, M
    Boerwinkle, E
    Sing, CF
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (02) : 595 - 612
  • [6] Di Rienzo A, 1998, GENETICS, V148, P1269
  • [7] Mode 3 technologies and the evolution of modern humans
    Foley, R
    Lahr, MM
    [J]. CAMBRIDGE ARCHAEOLOGICAL JOURNAL, 1997, 7 (01) : 3 - 36
  • [8] ARE EVOLUTIONARY RATES REALLY VARIABLE
    GILLESPIE, JH
    LANGLEY, CH
    [J]. JOURNAL OF MOLECULAR EVOLUTION, 1979, 13 (01) : 27 - 34
  • [9] GENETIC ABSOLUTE DATING BASED ON MICROSATELLITES AND THE ORIGIN OF MODERN HUMANS
    GOLDSTEIN, DB
    LINARES, AR
    CAVALLISFORZA, LL
    FELDMAN, MW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) : 6723 - 6727
  • [10] Monte Carlo inference methods in population genetics
    Griffiths, RC
    Tavare, S
    [J]. MATHEMATICAL AND COMPUTER MODELLING, 1996, 23 (8-9) : 141 - 158