Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain

被引：35

作者：

Hedgepeth, CM ^{[1
]}

Deardorff, MA ^{[1
]}

Klein, PS ^{[1
]}

机构：

[1] Univ Penn, Howard Hughes Med Inst, Sch Med, Dept Med,Div Hematol Oncol,Cell & Mol Biol Grad G, Philadelphia, PA 19104 USA

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 80卷 / 02期

关键词：

Xenopus; axin; glycogen synthase kinase-3 beta; midbrain; yeast two hybrid; development; forebrain-midbrain boundary; wnts;

D O I：

10.1016/S0925-4773(98)00203-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Axin is encoded by the fused locus in mice and is required for normal vertebrate axis formation. It has recently been shown that axin associates with the adenomatous polyposis coli gene product (APC), beta-catenin and glycogen synthase kinase-3 (GSK-3) in a complex that appears to regulate the level of cytoplasmic beta-catenin. We have identified the Xenopus homologue of axin through its interaction with GSK-3 beta. Xenopus axin (Xaxin) is expressed maternally and throughout early development with a low level of ubiquitous expression. Xaxin also shows remarkably high expression in the anterior mesencephalon adjacent to the forebrain-midbrain boundary. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：147 / 151

页数：5

共 18 条

[1] Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].