Stimulated Release of Size-Selected Cargos in Succession from Mesoporous Silica Nanoparticles

被引：154

作者：

Wang, Cheng ^{[3
,4
]}

Li, Zongxi ^{[1
,2
]}

Cao, Dennis ^{[3
,4
,5
,6
]}

Zhao, Yan-Li ^{[3
,4
]}

Gaines, Justin W. ^{[3
,4
]}

Bozdemir, O. Altan ^{[3
,4
]}

Ambrogio, Michael W. ^{[3
,4
]}

Frasconi, Marco ^{[3
,4
]}

Botros, Youssry Y. ^{[3
,4
,7
,8
]}

Zink, Jeffrey I. ^{[1
,2
]}

Stoddart, J. Fraser ^{[3
,4
,5
,6
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[3] Northwestern Univ, Ctr Chem Integrated Syst, Dept Chem, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Mat Sci, Evanston, IL 60208 USA

[5] Korea Adv Inst Sci & Technol, NanoCentury KAIST Inst, Taejon 305701, South Korea

[6] Korea Adv Inst Sci & Technol, Grad Sch EEWS WCU, Taejon 305701, South Korea

[7] Intel Labs, Santa Clara, CA 95054 USA

[8] King Abdulaziz City Sci & Technol, Natl Ctr Nano Technol Res, Riyadh 11442, Saudi Arabia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 22期

基金：

美国国家科学基金会;

关键词：

ss-cyclodextrins; cargo release; drug delivery; nanostructures; nanotechnology; INTRACELLULAR CONTROLLED-RELEASE; RESPONSIVE CONTROLLED-RELEASE; CONTROLLED DRUG-RELEASE; CANCER-CELLS; MOLECULAR RECOGNITION; COMBINATION THERAPY; INCLUSION-COMPOUNDS; DELIVERY; NANOCONTAINERS; CYCLODEXTRINS;

D O I：

10.1002/anie.201107960

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two birds with one stone: Covalent attachment of β-cyclodextrin rings (yellow; see figure) to mesoporous silica nanoparticles (MSNs) results in a dual-cargo release system into which differently sized cargos (blue and red spheres) can be loaded and then released in sequence when triggered by two different stimuli. The smaller molecules are released by lowering the pH value and the larger ones released after cleavage of the cyclodextrins from the MSN surface. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5460 / 5465

页数：6

共 81 条

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