Efficient and selective deuteration of phenylalanine derivatives catalyzed by Pd/C

被引：54

作者：

Maegawa, T ^{[1
]}

Akashi, A ^{[1
]}

Esaki, H ^{[1
]}

Aoki, F ^{[1
]}

Sajiki, H ^{[1
]}

Hirota, K ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Med Chem Lab, Gifu 5028585, Japan

来源：

SYNLETT | 2005年 / 05期

关键词：

palladium; catalysis; amino acids; deuteration; regio-selectivity;

D O I：

10.1055/s-2005-863730

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient deuteration method of phenylalanine derivatives using a Pd/C-H-2-D2O system has been developed. Selective deuteration at the beta-position of phenylalanine derivatives occurred using Pd/C as a catalyst with high deuterium efficiency without racemization at 110 degrees C. Also, the alpha-position was deuterated at higher temperature.

引用

页码：845 / 847

页数：3

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