Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome

被引：154

作者：

Van den Eynde, BJ

Morel, S

机构：

[1] Ludwig Inst Canc Res, Brussels Branch, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Cellular Genet Unit, B-1200 Brussels, Belgium

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(00)00197-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Upon exposure to IFN-gamma, the standard proteasome is replaced by the immunoproteasome, which contains LMP2, LMP7 and MECL1, and is considered more efficient at producing antigenic peptides presented to CD8(+) T cells. This view has been challenged this year by reports showing that some epitopes, mainly of self origin, are not processed by the immunoproteasome and that mature dendritic cells constitutively express immunoproteasomes and therefore cannot efficiently present such epitopes.

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页码：147 / 153

页数：7

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