Chemical characterization of Lycium barbarum polysaccharides and their reducing myocardial injury in ischemia/reperfusion of rat heart

被引：78

作者：

Lu Shao-Ping ^{[1
]}

Zhao Pin-Ting ^{[2
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, Xian 710038, Peoples R China

[2] Fourth Mil Med Univ, Tangdu Hosp, Dept Radiotherapy, Xian 710038, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 47卷 / 05期

关键词：

Fourier transform infrared spectroscopy; HPLC; Lycium barbarum polysaccharides; Cardiovascular diseases; Ischemia reperfusion; PROTEIN COMPLEX; FRUIT; EXPRESSION; EXTRACTS;

D O I：

10.1016/j.ijbiomac.2010.08.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Polysaccharides were extracted from Lycium barbarum fruits in this work Fourier transform Infrared spectroscopy (FT-IR) and high-performance liquid chromatography (HPLC) have been employed to characterize this polysaccharides in the present study The results of chemical composition indicated that the L. barbarum polysaccharides were composed of two kinds of monosaccharides namely glucose and fructose in molar ratios of 1 2 1 The results indicated that the glucose and fructose were the predominant monosaccharides IR spectrum of L barbarum polysaccharides revealed a typical peaks of polysaccharides The results still showed that L barbarum polysaccharides significantly decreased the myocardium LD level increased Na+-K+-ATPase and Ca2+-ATPase activities in heart ischemia reperfusion (IR) rats In addition L. barbarum polysaccharides still markedly decreased myocardium Bax positive rate and myocardial cell apoptosis and increased Bcl-2 positive rate in a dose-dependent manner It may be concluded that administration of L. barbarum polysaccharides can prevented the development of cardiovascular diseases (C) 2010 Elsevier B V All rights reserved

引用

页码：681 / 684

页数：4

共 24 条

[1]

AMRANI FE, 2009, J MED PLANTS RES, V3, P625

[2]

Attard E, 2009, J MED PLANTS RES, V3, P457

[3]

Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum [J].

Gan, L ;

Zhang, SH ;

Yang, XL ;

Xu, HB .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2004, 4 (04) :563-569

[4]

A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells [J].

Gan, L ;

Zhang, SH ;

Liu, Q ;

Xu, HB .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 471 (03) :217-222

[5]

Gao XM., 2000, Traditional Chinese Medicines, P1832

[6]

Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice [J].

Gong, HY ;

Shen, P ;

Jin, L ;

Xing, CH ;

Tang, F .

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2005, 20 (02) :155-162

[7]

Sialic acid: A novel marker of cardiovascular disease? [J].

Gopaul, Karina P. ;

Crook, Martin A. .

CLINICAL BIOCHEMISTRY, 2006, 39 (07) :667-681

[8]

Grosman, N .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2001, 1 (07) :1321-1329

[9]

Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity [J].

Ha, KT ;

Yoon, SJ ;

Choi, DY ;

Kim, DW ;

Kim, JK ;

Kim, CH .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 96 (03) :529-535

[10]

Protective effect of Potentilla anserine polysaccharide (PAP) on hydrogen peroxide induced apoptosis in murine splenic lymphocytes [J].

Hu, TingJun ;

Wei, Xiaojie ;

Zhang, Xia ;

Cheng, FuSheng ;

Shuai, XueHong ;

Zhang, Ling ;

Kang, Le .

CARBOHYDRATE POLYMERS, 2010, 79 (02) :356-361

← 1 2 3 →