Trypanocidal constituents in plants 2.: Xanthones from the stem bark of Garcinia subelliptica

被引：25

作者：

Abe, F

Nagafuji, S

Okabe, H

Higo, H

Akahane, H

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

[2] Fukuoka Univ, Sch Med, Jonan Ku, Fukuoka 8140180, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Mol Biol, Higashi Ku, Fukuoka 8128582, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 12期

关键词：

Trvpanosoma cruzi; Garcinia subelliptica; xanthone; trypanocidal activity; Chagas' disease; cytotoxicity;

D O I：

10.1248/bpb.26.1730

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methl-2-butenyl)xanthone. Their structures were determined by spectroscopic analysis. Trypanocidal activity against trypomastigotes, an infectious form of T. cruzi, was also estimated as well as cytotoxic activity. Fukugetin, the major component of the bark, showed no activity.

引用

页码：1730 / 1733

页数：4

共 25 条

[1] Trypanocidal constituents in plants 1.: Evaluation of some Mexican plants for their trypanocidal activity and active constituents in Guaco, roots of Aristolochia taliscana [J].