Antinuclear antibody in systemic sclerosis (scleroderma)

被引：123

作者：

Okano, Y

机构：

[1] Department of Medicine, Nippon Kokan Hospital, Kawasaki-ku, Kawasaki 210

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1996年 / 22卷 / 04期

关键词：

D O I：

10.1016/S0889-857X(05)70297-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Spontaneously occurring antinuclear antibodies (ANAs) can be found in systemic sclerosis (SSc). ANAs in SSc predominantly recognize DNA topoisomerase I (Scl-70), centromere proteins, RNA polymerase I, II, and III, and some nucleolar components, including fibrillarin, Th/To (RNase MRP/RNase P), and PM-Sd. Each antibody is known to Link to a subset characterized by clinical manifestations within the spectrum of SSc, thus its clinical importance is emphasized. Molecular studies of the autoantigens and immunogenetic associations with the ANA production may provide important insights into the relationship between the autoimmunity and SSc pathogens.

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页码：709 / +

页数：1

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