Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation

被引：152

作者：

Lipford, JR

Deshaies, RJ

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 10期

关键词：

D O I：

10.1038/ncb1003-845

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A growing literature points to a fundamental role for the ubiquitin - proteasome degradation system ( UPS) in transcription. Four recent publications add significant insight to our understanding of the connections between these processes. Each provides evidence that some aspect of the UPS can stimulate the activity of transcriptional activators. UPS might promote transcription by several mechanisms, and in some cases, even the final step of the UPS - proteolysis - might enhance activator function.

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收藏

页码：845 / 850

页数：6

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