CD1d-restricted NK T cells are dispensable for specific antibody responses and protective immunity against liver stage malaria infection in mice

被引：38

作者：

Romero, JF

Eberl, G

Macdonald, HR

Corradin, G ^{[1
]}

机构：

[1] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland

[2] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

来源：

PARASITE IMMUNOLOGY | 2001年 / 23卷 / 05期

关键词：

Plasmodium berghei; sporozoites; T lymphocytes; immunity;

D O I：

10.1046/j.1365-3024.2001.00381.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunization with a single dose of irradiated sporozoites is sufficient to induce protection against malaria in wild-type mice. Although this protection is classically attributed to conventional CD4(+) and CD8(+) T cells, several recent reports have suggested an important role for CD1-restricted NK T cells in immunity to malaria. in this study, we directly compared the ability of C57BL/6 wild-type and CD1-deficient mice to mount a protective immune response against Plasmodium berghei sporozoites. Our data indicate that CD1-restricted NK T cells are not required for protection in this model system. Moreover, specific IgG antibody responses to the P. berghei circumsporozoite repeat sequence were also unaffected by CD1 deficiency. Collectively, our data demonstrate that CD1-restricted NK T cells are dispensable for protective immunity to liver stage P. berghei infection.

引用

收藏

页码：267 / 269

页数：3

相关论文

共 15 条

[1] Mouse CD1-specific NK1 T cells: Development, specificity, and function [J].

Bendelac, A ;

Rivera, MN ;

Park, SH ;

Roark, JH .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :535-562

[2] Impaired NK1(+) T cell development and early IL-4 production in CD1-deficient mice [J].

Chen, YH ;

Chiu, NM ;

Mandal, M ;

Wang, N ;

Wang, CR .

IMMUNITY, 1997, 6 (04) :459-467

[3]

Doolan DL, 1999, J IMMUNOL, V163, P884

[4] NK1.1(+) T-CELL RECEPTOR-ALPHA/BETA(+) CELLS - NEW CLUES TO THEIR ORIGIN, SPECIFICITY, AND FUNCTION [J].

MACDONALD, HR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (03) :633-638

[5] IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses [J].

Magram, J ;

Connaughton, SE ;

Warrier, RR ;

Carvajal, DM ;

Wu, CY ;

Ferrante, J ;

Stewart, C ;

Sarmiento, U ;

Faherty, DA ;

Gately, MK .

IMMUNITY, 1996, 4 (05) :471-481

[6] Cutting edge: The IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: Exploring the role of GPIs in NK T cell activation and antimalarial responses [J].

Molano, A ;

Park, SH ;

Chiu, YH ;

Nosseir, S ;

Bendelac, A ;

Tsuji, M .

JOURNAL OF IMMUNOLOGY, 2000, 164 (10) :5005-5009

[7] T-CELL RESPONSES TO PREERYTHROCYTIC STAGES OF MALARIA - ROLE IN PROTECTION AND VACCINE DEVELOPMENT AGAINST PREERYTHROCYTIC STAGES [J].

NARDIN, EH ;

NUSSENZWEIG, RS .

ANNUAL REVIEW OF IMMUNOLOGY, 1993, 11 :687-727

[8] Liver CD4-CD8- NK1.1+ TCRαβ intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro [J].

Pied, S ;

Roland, J ;

Louise, A ;

Voegtle, D ;

Soulard, V ;

Mazier, D ;

Cazenave, PA .

JOURNAL OF IMMUNOLOGY, 2000, 164 (03) :1463-1469

[9]

RODRIGUES M, 1993, IMMUNOLOGY, V80, P1

[10] Synthesis and immunological characterization of 104-mer and 102-mer peptides corresponding to the N- and C-terminal regions of the Plasmodium falciparum CS protein [J].

Roggero, MA ;

Filippi, B ;

Church, P ;

Hoffman, SL ;

BlumTirouvanziam, U ;

Lopez, JA ;

Esposito, F ;

Matile, H ;

Reymond, CD ;

Fasel, N ;

Corradin, G .

MOLECULAR IMMUNOLOGY, 1995, 32 (17-18) :1301-1309