Concordance between four European centres of PET reporting criteria designed for use in multicentre trials in Hodgkin lymphoma

被引:268
作者
Barrington, Sally F. [1 ]
Qian, Wendi [2 ]
Somer, Edward J. [1 ]
Franceschetto, Antonella [3 ]
Bagni, Bruno [3 ]
Brun, Eva [4 ,5 ]
Almquist, Helen [4 ,5 ]
Loft, Annika [6 ]
Hojgaard, Liselotte [6 ]
Federico, Massimo [7 ]
Gallamini, Andrea [8 ]
Smith, Paul [9 ,10 ]
Johnson, Peter [11 ]
Radford, John [12 ,13 ]
O'Doherty, Michael J. [1 ]
机构
[1] Kings Coll London, PET Imaging Ctr St Thomas, Div Imaging, London SE1 7EH, England
[2] MRC Clin Trials Unit, London, England
[3] Univ Modena & Reggio Emilia, Dept Nucl Med, Modena, Italy
[4] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
[5] Univ Lund Hosp, Dept Clin Physiol, S-22185 Lund, Sweden
[6] Copenhagen Univ Hosp, Rigshosp, PET & Cyclotron Unit, Copenhagen, Denmark
[7] Univ Modena & Reggio Emilia, Dept Haematol & Oncol, Modena, Italy
[8] Azienda Osped S Croce e Carle, Dept Hematol, Cuneo, Italy
[9] Canc Res UK, London, England
[10] UCL Canc Trials Ctr, London, England
[11] Canc Res UK Clin Ctr, Southampton, Hants, England
[12] Christie NHS Fdn Trust, Manchester, Lancs, England
[13] Univ Manchester, Manchester, Lancs, England
关键词
Positron emission tomography; Hodgkin lymphoma; Quality control/quality assurance; Clinical trial; POSITRON-EMISSION-TOMOGRAPHY; B-CELL LYMPHOMA; SUV-BASED ASSESSMENT; FDG-PET; F-18-FDG PET; RESPONSE ASSESSMENT; PROGNOSTIC VALUE; PROGRESSION-FREE; CYCLES; INTERIM;
D O I
10.1007/s00259-010-1490-5
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To determine if PET reporting criteria for the Response Adapted Treatment in Hodgkin Lymphoma (RATHL) trial could enable satisfactory agreement to be reached between 'core' laboratories operating in different countries. Four centres reported scans from 50 patients with stage II-IV HL, acquired before and after two cycles of Adriamycin/bleomycin/vinblastine/dacarbazine. A five-point scale was used to score response scans using 'normal' mediastinum and liver as reference levels. Centres read scans independently of each other. The level of agreement between centres was determined assuming (1) that uptake in sites involved at diagnosis that was higher than liver uptake represented disease (conservative reading), and (2) that uptake in sites involved at diagnosis that was higher than mediastinal uptake represented disease (sensitive reading). There was agreement that the response scan was 'positive' or 'negative' for lymphoma in 44 patients with a conservative reading and in 41 patients with a sensitive reading. Kappa was 0.85 (95% CI 0.74-0.96) for conservative reading and 0.79 (95% CI 0.67-0.90) for sensitive reading. Agreement was reached in 46 and 44 patients after discussion for the conservative and sensitive readings, respectively. The criteria developed for reporting in the RATHL trial are sufficiently robust to be used in a multicentre setting.
引用
收藏
页码:1824 / 1833
页数:10
相关论文
共 27 条
  • [1] Altman D, 1999, SOME COMMON PROBLEMS, P396
  • [2] Limitations of PET for imaging lymphoma
    Barrington, Sally F.
    O'Doherty, Michael J.
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (Suppl 1) : S117 - S127
  • [3] PET/CT with intravenous contrast can be used for PET attenuation correction in cancer patients
    Berthelsen, AK
    Holm, S
    Loft, A
    Klausen, TL
    Andersen, F
    Hojgaard, L
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2005, 32 (10) : 1167 - 1175
  • [4] Evaluation of response: is 18F-FDG PET the answer?
    Chiti, Arturo
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 36 (05) : 733 - 734
  • [5] A COEFFICIENT OF AGREEMENT FOR NOMINAL SCALES
    COHEN, J
    [J]. EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT, 1960, 20 (01) : 37 - 46
  • [6] Combined PET and low-dose, noncontrast CT scanning obviates the need for additional diagnostic contrast-enhanced CT scans in patients undergoing staging or restaging for lymphoma
    Elstrom, R. L.
    Leonard, J. P.
    Coleman, M.
    Brown, R. K. J.
    [J]. ANNALS OF ONCOLOGY, 2008, 19 (10) : 1770 - 1773
  • [7] Interobserver variability in the detection of cervical-thoracic Hodgkin's disease by computed tomography
    Fletcher, BD
    Glicksman, AS
    Gieser, P
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (07) : 2153 - 2159
  • [8] Early interim 2-[18F]Fluoro-2-Deoxy-D-Glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma:: A report from a joint Italian-Danish study
    Gallamini, Andrea
    Hutchings, Martin
    Rigacci, Luigi
    Specht, Lena
    Merli, Francesco
    Hansen, Mads
    Patti, Caterina
    Loft, Annika
    Di Raimondo, Francesco
    D'Amore, Francesco
    Biggi, Alberto
    Vitolo, Umberto
    Stelitano, Caterina
    Sancetta, Rosario
    Trentin, Livio
    Luminari, Stefano
    Iannitto, Emilio
    Viviani, Simonetta
    Pierri, Ivana
    Levis, Alessandro
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (24) : 3746 - 3752
  • [9] Gallamini A, 2006, HAEMATOLOGICA, V91, P475
  • [10] High incidence of false-positive PET scans in patients with aggressive non-Hodgkin's lymphoma treated with rituximab-containing regimens
    Han, H. S.
    Escalon, M. P.
    Hsiao, B.
    Serafini, A.
    Lossos, I. S.
    [J]. ANNALS OF ONCOLOGY, 2009, 20 (02) : 309 - 318