Continuous infusion therapy in haemophilia

被引:24
作者
Varon, D [1 ]
Martinowitz, U [1 ]
机构
[1] Chaim Sheba Med Ctr, Natl Hemophilia Ctr, IL-52621 Tel Hashomer, Israel
关键词
continuous infusion; haemophilia; von Willebrand disease;
D O I
10.1046/j.1365-2516.1998.440431.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The application of coagulation factor therapy by continuous infusion (CI) was first suggested by Brinkhous in the early 1950s [1]. The recent introduction of this mode of therapy to everyday practice was made possible after the demonstration of a good stability of most factor concentrates which were also found safe regarding potential bacterial contamination. Other developments included a better understanding of the pharmacokinetics of factors concentrates as well as the availability of a new delivery system. Continuous infusion was shown to be superior to bolus injection (Bf) in achieving a stabile haemostatic effect, in the prevention of post-operative bleeding and was found to save between 20-50% in the required factor. This mode of therapy was found effective in haemophilia A and B as well as among patients with inhibitors to FVIII and with von Willebrand disease (vWD).
引用
收藏
页码:431 / 435
页数:5
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