Visfatin Inhibits Apoptosis and Necrosis of Hippocampus CA3 Cells Following Transient Global Ischemia/Reperfusion in Rats

被引：22

作者：

Erfani, Sohaila ^{[1
]}

Aboutaleb, Nahid ^{[2
,3
]}

Oryan, Shahrbanoo ^{[1
]}

Shamsaei, Nabi ^{[4
]}

Khaksari, Mehdi ^{[5
]}

Kalalian-Moghaddam, Hamid ^{[5
]}

Nikbakht, Farnaz ^{[2
,3
]}

机构：

[1] Kharazmi Univ, Fac Biol, Dept Anim Physiol, Tehran, Iran

[2] Iran Univ Med Sci, Fac Med, Physiol Res Ctr, Tehran, Iran

[3] Iran Univ Med Sci, Fac Med, Dept Physiol, Tehran, Iran

[4] Ilam Univ, Fac Literature & Humanities, Dept Phys Educ & Sports Sci, Ilam, Iran

[5] Shahroud Univ Med Sci, Sch Med, Shahroud, Iran

来源：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS | 2015年 / 21卷 / 02期

基金：

美国国家科学基金会;

关键词：

Visfatin; Apoptosis; Ischemia; Reperfusion; Hippocampus; ISCHEMIC REPERFUSION INJURY; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE PROTECTS; SELECTIVE VULNERABILITY; BRAIN; MODEL; MECHANISMS; APELIN-13; STROKE;

D O I：

10.1007/s10989-014-9449-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Visfatin, a novel adipokine, is predominantly produced by visceral adipose tissue and it has been linked to a diverse variety of cellular processes and it is an important factor in cell apoptosis and survival. Cerebral ischemia causes loss of hippocampus pyramidal cells. In this study, we investigated the neuroprotective effects of visfatin in rats after global cerebral ischemia. Both common carotid arteries were occluded for 20 min followed by reperfusion. Saline as a vehicle and visfatin at doses of 100 ng were injected intracerebro-ventriculary at the time of cerebral reperfusion. Apoptosis and necrosis were assessed 96 h after ischemia. The results showed that treatment with visfatin significantly reduces apoptosis (P < 0.05) and necrotic cell death (P < 0.001) in hippocampal CA3 area, compared to the ischemia group. In conclusion, visfatin treatment, found for the first time in the present study, reduces hippocampus CA3 injuries after cerebral ischemia through preventing neuronal necrosis and apoptosis.

引用

页码：223 / 228

页数：6

共 30 条

[1]

Apelin-13 Inhibits Apoptosis of Cortical Neurons Following Brain Ischemic Reperfusion Injury in a Transient Model of Focal Cerebral Ischemia [J].