No evidence for association and linkage disequilibrium between dyslexia and markers of four dopamine-related genes

被引：38

作者：

Marino, C

Giorda, R

Vanzin, L

Molteni, M

Lorusso, ML

Nobile, M

Baschirotto, C

Alda, M

Battaglia, M

机构：

[1] Sci Inst Eugenio Medea, Dept Child Psychiat, I-23842 Bosisio Parini, LC, Italy

[2] Mol Biol Lab, I-23842 Bosisio Parini, LC, Italy

来源：

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY | 2003年 / 12卷 / 04期

关键词：

dyslexia; genetics; TDT; dopamine receptors;

D O I：

10.1007/s00787-003-0332-4

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 [发展与教育心理学];

摘要：

Dopamine genes are candidate genes for dyslexia in the light of the well-known comorbidity between dyslexia and ADHD. Within-family association and linkage disequilibrium were tested between four genetic markers at DRD4, DRD3, DRD2, and DAT loci, and dyslexia, in a sample of 130 Italian dyslexic children, 16.9% of whom had comorbid ADHD. No evidence of either association or linkage disequilibrium was found, neither in the total sample nor in the comorbid subgroup. Negative results do not support a common genetic basis between these two disorders for these markers.

引用

页码：198 / 202

页数：5

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