Reprogrammed genetic decoding in cellular gene expression

被引：195

作者：

Namy, O

Rousset, JP

Napthine, S

Brierley, I

机构：

[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

[2] Univ Paris 11, Inst Genet & Microbiol, Lab Genet Mol Traduct, F-91405 Orsay, France

来源：

MOLECULAR CELL | 2004年 / 13卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1097-2765(04)00031-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reprogrammed genetic decoding signals in mRNAs productively overwrite the normal decoding rules of translation. These "recoding" signals are associated with sites of programmed ribosomal frameshifting, hopping, termination codon suppression, and the incorporation of the unusual amino acids selenocysteine and pyrrolysine. This review summarizes current knowledge of the structure and function of recoding signals in cellular genes, the biological importance of recoding in gene regulation, and ways to identify new recoded genes.

引用

收藏

页码：157 / 168

页数：12

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