Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men

被引:174
作者
Schacker, T
Zeh, J
Hu, HL
Hill, E
Corey, L
机构
[1] Fred Hutchinson Canc Res Ctr, Program Infect Dis, Seattle, WA 98104 USA
[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[3] Univ Washington, Dept Med, Seattle, WA USA
[4] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA
[5] Univ Washington, Dept Stat, Seattle, WA 98195 USA
[6] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
[7] Glaxo Wellcome, Chapel Hill, NC USA
关键词
D O I
10.1086/314486
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Herpes simplex virus (HSV) infection is common in persons coinfected with human immunodeficiency virus (HIV), In a prospective study, daily viral cultures of the mouth, genitals, and rectum were collected from 68 HIV-positive and 13 HIV-negative men who have sex with men, Subjects completed a median of 57 days of follow-up. Anogenital HSV-2 cultures were positive on 405 (9.7%) of 4167 days for HIV-positive men and on 24 (3.1%) of 766 days for HIV-negative men. Most reactivations were perirectal and subclinical, Risk factors for increased HSV-2 shedding among HIV-positive men were low CD4 cell count (odds ratio, 2.5; 95% confidence interval, 1.2-5.4) and antibodies to both HSV-1 and HSV-2 versus HSV-2 only (odds ratio, 1.9; 95% confidence interval, 1.0-3.7), Three isolates obtained from 3 separate subjects were resistant to acyclovir, Thus, subclinical HSV-2 reactivation is an important opportunistic infection in persons with HIV infection. Further studies are necessary to determine the impact of subclinical HSV-2 reactivation on the natural history of HIV infection.
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页码:1616 / 1622
页数:7
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