Asymmetric reduction of ketoxime ethers to optically active O-substituted hydroxylamines with reagents prepared from borane and chiral amino alcohols

被引：22

作者：

Dougherty, JT

Flisak, JR

Hayes, J

Lantos, I

Liu, L

Tucker, L

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,TONBRIDGE,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(97)00007-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric reduction of ketoxime ethers to yield enantiomerically enriched chiral hydroxylamines with reagents prepared from borane and norephedrine has been investigated. Very high enantioselectivity (ca. 99% ee) was obtained in the reduction of ketoxime O-(o-nitrobenzyl) ether to O-(o-nitrobenzyl) hydroxylamine. (C) 1997 Elsevier Science Ltd.

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页码：497 / 499

页数：3

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