Embryonic asymmetry: The left side gets all the best genes

被引:16
作者
King, T [1 ]
Brown, NA [1 ]
机构
[1] St George Hosp, Sch Med, Dept Anat & Dev Biol, London SW17 0RE, England
关键词
D O I
10.1016/S0960-9822(99)80036-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The origin of left-right developmental asymmetry is a continuing puzzle, but some recent results provide new insights into the steps leading to organ asymmetry implicating the homeobox protein Pitz-2 in one key step - and others support a model of symmetry-breaking that involves the chirality of microtubules.
引用
收藏
页码:R18 / +
页数:6
相关论文
共 30 条
  • [1] Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development
    Biben, C
    Harvey, RP
    [J]. GENES & DEVELOPMENT, 1997, 11 (11) : 1357 - 1369
  • [2] BROWN NA, 1990, DEVELOPMENT, V109, P1
  • [3] Mutation of the mouse hepatocyte nuclear factor forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry
    Chen, JC
    Knowles, HJ
    Hebert, JL
    Hackett, BP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (06) : 1077 - 1082
  • [4] Chen JN, 1997, DEVELOPMENT, V124, P4373
  • [5] Dufort D, 1998, DEVELOPMENT, V125, P3015
  • [6] Endow SA, 1998, BIOESSAYS, V20, P108, DOI 10.1002/(SICI)1521-1878(199802)20:2<108::AID-BIES2>3.0.CO
  • [7] 2-P
  • [8] Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1
    Firulli, AB
    McFadden, DG
    Lin, Q
    Srivastava, D
    Olson, EN
    [J]. NATURE GENETICS, 1998, 18 (03) : 266 - 270
  • [9] X-linked situs abnormalities result from mutations in ZIC3
    Gebbia, M
    Ferrero, GB
    Pilia, G
    Bassi, MT
    Aylsworth, AS
    PenmanSplitt, M
    Bird, LM
    Bamforth, JS
    Burn, J
    Schlessinger, D
    Nelson, DL
    Casey, B
    [J]. NATURE GENETICS, 1997, 17 (03) : 305 - 308
  • [10] The left-right coordinator: The role of Vg1 in organizing left-right axis formation
    Hyatt, BA
    Yost, HJ
    [J]. CELL, 1998, 93 (01) : 37 - 46