Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

被引：64

作者：

Takeda, A

Yasuda, T

Miyata, T

Mizuno, K

Li, M

Yoneyama, S

Horie, K

Maeda, K

Sobue, G

机构：

[1] NAGOYA UNIV,SCH MED,DEPT NEUROL,NAGOYA,AICHI 466,JAPAN

[2] OYAMADA MEM SPA HOSP,DEPT NEUROL,YOKKAICHI 51011,JAPAN

[3] NAGOYA UNIV,SCH MED,BRANCH HOSP,DEPT INTERNAL MED,NAGOYA,AICHI 461,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 221卷 / 01期

关键词：

advanced glycation end products; aging; Alzheimer's disease; beta-amyloid protein; neuron;

D O I：

10.1016/S0304-3940(96)13275-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains without dementia, but not in young brains less than 17 years of age. Extra-neuroperikaryal AGE deposits were also detected in the neuropil of AD and aged brains. The extra-neuroperikaryal AGE deposits markedly increased in AD brains as compared to aged brains. These AGE-positive deposits in the neuropil were nor related to the senile plaque identified by anti-beta amyloid protein antibody. These findings suggest a potential link of AGE accumulation in the central nervous system to the aging process of neurons and the degenerating process of AD neurons. (C) 1996 Elsevier Science Ireland Ltd.

引用

页码：17 / 20

页数：4

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