Trends in the prognosis of patients with primary metastatic breast cancer diagnosed between 1975 and 2002

We performed a population-based study, including 1089 patients with primary metastatic breast cancer, diagnosed in South-East Netherlands between 1975 and 2002, and tried to give an answer to the question if prognosis of this patient group has improved or not. Follow-up was completed until 1 January 2005. The median survival times for patients with primary metastatic disease were 18, 17 and 20.5 months for patients diagnosed in the periods 1975-1984, 1985-1994 and 1995-2002, respectively. A multivariate analysis, including age, tumour size and information on the localization of metastatic disease and the number of metastatic sites, showed that patients diagnosed in the period 1995-2002 had a 18% tower death risk (95% confidence interval 5-30) compared to those diagnosed in the period 1985-1994. These data show that the prognosis of patients with primary metastatic breast cancer remained unchanged between 1975 and 1994 and that some progress has been made after 1994. (C) 2007 Elsevier Ltd. All rights reserved.