PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic

被引：34

作者：

Kane, Lesley A. ^{[1
]}

Youle, Richard J. ^{[1
]}

机构：

[1] NINDS, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2011年 / 147卷 / 04期

关键词：

GTPASE;

D O I：

10.1016/j.cell.2011.10.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PINK1 and Parkin also regulate mitochondrial trafficking and quarantine damaged mitochondria by severing their connection to the microtubule network.

引用

收藏

页码：721 / 723

页数：4

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