Constitutively activated CK2 potentially plays a pivotal role in Theileria-induced lymphocyte transformation

被引:22
作者
Dessauge, F
Lizundia, R
Langsley, G
机构
[1] Hop Cochin, Lab Biol Cellulaire Comparat Apicomplexes, CNRS,UMR 8104, Dept Malad Infect,Inst Cochin,INSERM,U567, F-75014 Paris, France
[2] Grp Hosp Pitie Salpetriere, Lab Immunol Cellulaire & Tissulaire, INSERM, U543, F-75651 Paris, France
关键词
Theileria; transformation; CK2; Myc; apoptosis;
D O I
10.1017/S0031182005008140
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Activation of casein kinase II (CK2) was one of the first observations made on how Theileria parasites manipulate host cell signal transduction pathways and we argue that CK2 induction may in fact contribute to many of the different activation events that have been described since 1993 for Theileria-infected lymphocytes such as sustained activation of transcription factors c-Myc and NF-kappa B. CK2 also contributes to infected lymphocyte survival by inhibiting caspase activation and is probably behind constitutive PI3-K activation by phosphorylating PTEN. Finally, we also discuss how CK2A may act not only as a kinase, but also as a stimulatory subunit for the protein phosphatase PP2A, so dampening down the MEK/ERK and Akt/PKB pathways and for all these reasons we propose CK2 as a central player in Theileria-induced lymphocyte transformation.
引用
收藏
页码:S37 / S44
页数:8
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