Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency

被引：14

作者：

Rocha, Monica S. ^{[1
,2
]}

Teerlink, Tom ^{[1
]}

Janssen, Mirian C. H. ^{[3
]}

Kluijtmans, Leo A. J. ^{[4
]}

Smulders, Yvo ^{[5
]}

Jakobs, Cornelis ^{[1
]}

de Almeida, Isabel Tavares ^{[2
,6
]}

Rivera, Isabel ^{[2
,6
]}

Castro, Rita ^{[2
,6
]}

Blom, Henk J. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res ICAR VU, Metab Unit,Dept Clin Chem, NL-1081 HV Amsterdam, Netherlands

[2] Univ Lisbon, Fac Pharm, Inst Med & Pharmaceut Sci iMed UL, P-1699 Lisbon, Portugal

[3] Radboud Univ Nijmegen, Med Ctr, Dept Gen Internal Med, NL-6525 ED Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Lab Genet Endocrine & Metab Dis, Dept Lab Med, NL-6525 ED Nijmegen, Netherlands

[5] Vrije Univ Amsterdam, Med Ctr, Inst Cardiovasc Res ICAR VU, Dept Internal Med, NL-1081 HV Amsterdam, Netherlands

[6] Univ Lisbon, Fac Pharm, Dept Biochem & Human Biol, P-1699 Lisbon, Portugal

来源：

ATHEROSCLEROSIS | 2012年 / 222卷 / 02期

关键词：

Hyperhomocysteinemia; Cystathionine beta-synthase deficiency; ADMA; SYMMETRIC DIMETHYLARGININE; ENDOTHELIAL FUNCTION; HUMAN-PLASMA; ARGININE; HYPERHOMOCYSTEINAEMIA; HOMOCYSTEINE; ADMA;

D O I：

10.1016/j.atherosclerosis.2012.03.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In hyperhomocysteinemia (HHcy), an independent risk factor for cardiovascular diseases, endothelial dysfunction due to reduced bioavailability of nitric oxide is a consistent finding. However, the underlying mechanisms remain unknown. Increased levels of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) have been associated with HHcy, and may contribute, at least in part, for the homocysteine-induced endothelial dysfunction, but whether cystathionine beta-synthase (CBS) deficiency is associated with increased ADMA has hardly been investigated. To address this question, we measured total homocysteine (tHcy), ADMA and symmetric dimethylarginine (SDMA) in plasma of 22 adult CBS deficient patients, using established HPLC techniques. Results showed that in CBS deficient patients with elevated levels of tHcy (median (total range): 33 (14-237) mu mol/L), both ADMA and SDMA levels were normal. Moreover, tHcy and ADMA concentrations were not correlated (r(s) = 0.017, p = 0.94). Our results favor the hypothesis that the negative vascular effects of HHcy have an ADMA-independent etiology. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：509 / 511

页数：3

共 19 条

[1] DETERMINATION OF FREE AND TOTAL HOMOCYSTEINE IN HUMAN-PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION [J].