Extracellular protons activate K+ current in a subpopulation of frog taste receptor cells

被引：6

作者：

Bobkov, YV ^{[1
]}

Kolesnikov, SS ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cell Biophys, Moscow 142292, Russia

来源：

NEUROSCIENCE LETTERS | 1999年 / 264卷 / 1-3期

关键词：

potassium channels; sour transduction; taste receptor cells;

D O I：

10.1016/S0304-3940(99)00170-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Based on morphological and electrophysiological criteria, two distinct subpopulations (group A and group B) taste receptor cells (TRCs) isolated from frog (Rana temporaria) taste disks were identified. TRCs from the group A were depolarized by acid stimuli which, in contrast, caused hyperpolarizing responses in group B TRCs. By using patch clamp technique we explored ion mechanisms mediating the pH dependent TRC hyperpolarization, and found that K+ conductance of TRCs from the group B increased as bath solution pH reduced. Our findings provide rationale to hypothesize that TRC from the group B express Ht gated K+ channels. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：25 / 28

页数：4

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