Use of mycophenolate mofetil for prevention of acute rejection in renal transplantation

被引：5

作者：

Carl, S ^{[1
]}

Wiesel, M ^{[1
]}

Staehler, G ^{[1
]}

机构：

[1] Univ Heidelberg, Chirurg Klin, Abt Urol & Poliklin, D-69120 Heidelberg, Germany

来源：

UROLOGE-AUSGABE A | 1998年 / 37卷 / 03期

关键词：

immunosuppressive therapy; anti-rejection treatment; mycophenolate mofetil; multicenter trial;

D O I：

10.1007/s001200050185

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

1493 patients were enrolled in 55 centers in Europe, Canada, Australia and the USA comparing the efficacy of mycophenolate mofetil (MMF) in daily doses of 2 and 3 g with placebo/azathioprine (PLA/AZA) for the prevention of acute rejection in renal transplant patients. Acute rejections and graft loss and death at 1 year were measured per trial and these data were combined and analyzed in a pooled fashion. The three pooled treatment groups were well balanced regarding demographic characteristics and cause of renal failure leading to transplantation. At one year the graft survival rate was 90.4 % and 89.2 % in the MMF 2 g and 3 g groups compared with 87.6 % in the PLA/AZA-group. MMF 2 and 3 g were significantly better than PLA/AZA in reducing biopsy proven rejection at one year: 40.8 % placebo/aza vs. 19.8 % in the MMF 2 g group and 16.5 % in the MMF 3 g group.

引用

页码：282 / 286

页数：5

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