Mercury-specific lymphocytes: An indication of mercury allergy in man

被引:58
作者
Stejskal, VDM [1 ]
Forsbeck, M [1 ]
Cederbrant, KE [1 ]
Asteman, O [1 ]
机构
[1] SOPHIAHEMMET,STOCKHOLM,SWEDEN
关键词
cell-mediated immunity; silver amalgam; mercury; human memory lymphocytes; MELISA;
D O I
10.1007/BF01540970
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this study, 18 patients with oral lichen planus (OLP), adjacent to amalgam fillings, were tested in vitro with an optimized lymphocyte proliferation test, MELISA (memory lymphocyte immunostimulation assay) and with a patch test. Twenty subjects with amalgam fillings but without oral discomfort and 12 amalgam-free subjects served as controls. The results show that patients with OLP have significantly higher lymphocyte reactivity to inorganic mercury, a corrosion product of amalgam, compared to control groups. Removal of amalgam fillings resulted in the disappearance of oral mucosal changes, thus indicating a causal relationship. Positive responses to phenylmercury (phenyl-Hg), a bactericidal agent in rootfillings and in pharmaceutical preparations, were also noted in the oral lichen group but not in the control groups. Thus, low-grade chronic exposure to mercury may induce a state of systemic sensitization as verified by Hg-specific lymphocyte reactivity in vitro.
引用
收藏
页码:31 / 40
页数:10
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