Energy, macronutrients and laryngeal cancer risk

被引:12
作者
Bosetti, C
La Vecchia, C
Talamini, R
Negri, E
Levi, F
Fryzek, J
McLaughlin, JK
Garavello, W
Franceschi, S
机构
[1] Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy
[2] Univ Milan, Ist Stat Med & Biometria, I-20122 Milan, Italy
[3] Ctr Riferimento Oncol, Serv Epidemiol, I-33081 Aviano, PN, Italy
[4] CHU Vaudois, Inst Univ Med Sociale & Prevent, Registre Vaudois Tumeurs, CH-1011 Lausanne, Switzerland
[5] Int Epidemiol Inst, Rockville, MD USA
[6] Univ Milano Bicocca, Osped San Gerardo, Monza, Italy
[7] Int Agcy Res Canc, F-69372 Lyon, France
关键词
case-control study; diet; laryngeal cancer; nutrients; risk factors;
D O I
10.1093/annonc/mdg251
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: A role for diet in laryngeal carcinogenesis has been suggested, but only a few studies have examined the potential relationship with a wide variety of macronutrients. Patients and methods: A case-control study was conducted between 1992 and 2000 in Italy and Switzerland, including 527 incident cases of laryngeal cancer, and 1297 controls hospitalized for acute, non-neoplastic conditions. The subjects' usual diet was investigated through a validated food frequency questionnaire, including 78 foods and beverages. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models. Results: Cases reported higher energy intake than controls. The continuous OR for 100 kcal/day was 1.16 (95% CI 1.12-1.21) for alcohol energy, and 1.02 (95% CI 1.01-1.04) for non-alcohol energy. A significantly increased risk of laryngeal cancer was observed for animal protein (continuous OR = 1.21, 95% CI 1.03-1.41), polyunsaturated fats other than linoleic and linolenic fatty acids (OR = 1.43, 95% CI 1.19-1.70), and cholesterol intake (OR = 1.43, 95% CI 1.19-1.71). Laryngeal cancer risk was slightly reduced with increasing vegetable protein (OR = 0.75, 95% CI 0.62-0.91), sugar (OR = 0.84, 95% CI 0.71-1.00) and monounsaturated fatty acid intake (OR = 0.83, 95% CI 0.70-0.99). Conclusions: Laryngeal cancer cases have a higher energy intake than control subjects, and report a higher intake of animal protein and cholesterol.
引用
收藏
页码:907 / 912
页数:6
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