Cholinergic foundations of Alzheimer's disease therapy

被引：57

作者：

Giacobini, E ^{[1
]}

机构：

[1] Univ Hosp Geneva, Dept Geriatr, HUG, CH-1226 Geneva, Switzerland

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 3-4期

关键词：

cholinesterase inhibitors; Alzheimer's disease;

D O I：

10.1016/S0928-4257(98)80034-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cholinesterase inhibitors (ChEI) represent the drug of choice for Alzheimer's disease (AD) treatment. They produce significant improvement on cognitive as well as non-cognitive function for a period up to 1 year during the first 3 years following clinical diagnosis. The magnitude of cognitive improvements is similar for different ChEI, however, differences are seen with regard to incidence and severity of side effects, optimal ChE inhibition, pharmacokinetic properties and mode of administration. ((C)Elsevier, Paris).

引用

页码：283 / 287

页数：5

共 36 条

[1]

ANAND R, 1996, ALZHEIMER DIS MOL BI, P239

[2]

BECKER R, 1996, ALZ DIS ASSOC DIS, V1, P124

[3] MECHANISMS OF CHOLINESTERASE INHIBITION IN SENILE DEMENTIA OF THE ALZHEIMER TYPE - CLINICAL, PHARMACOLOGICAL, AND THERAPEUTIC ASPECTS [J].

BECKER, RE ;

GIACOBINI, E .

DRUG DEVELOPMENT RESEARCH, 1988, 12 (3-4) :163-195

[4] PHARMACOKINETICS AND PHARMACODYNAMICS OF ACETYLCHOLINESTERASE INHIBITION - CAN ACETYLCHOLINE LEVELS IN THE BRAIN BE IMPROVED IN ALZHEIMERS-DISEASE [J].

BECKER, RE ;

GIACOBINI, E .

DRUG DEVELOPMENT RESEARCH, 1988, 14 (3-4) :235-246

[5] EFFECTS OF METRIFONATE, A LONG-ACTING CHOLINESTERASE INHIBITOR, IN ALZHEIMER-DISEASE - REPORT OF AN OPEN TRIAL [J].

BECKER, RE ;

COLLIVER, J ;

ELBLE, R ;

FELDMAN, E ;

GIACOBINI, E ;

KUMAR, V ;

MARKWELL, S ;

MORIEARTY, P ;

PARKS, R ;

SHILLCUTT, SD ;

UNNI, L ;

VICARI, S ;

WOMACK, C ;

ZEC, RF .

DRUG DEVELOPMENT RESEARCH, 1990, 19 (04) :425-434

[6]

Becker RE, 1996, ALZHEIMER DIS MOL BI, P257

[7]

CANAL I, 1996, CLIN PHARMACOL THER, V15, P49

[8]

CUMMINGS MD, 1998, IN PRESS NEUROLOGY

[9]

Dale HH, 1914, J PHARMACOL EXP THER, V6, P147

[10]

DAVIS KL, 1979, NEW ENGL J MED, V301, P946

← 1 2 3 4 →