Glycolaldehyde induces apoptosis in a human breast cancer cell line

被引：15

作者：

Al-Maghrebi, MA

Al-Mulla, F

Benov, LT

机构：

[1] Kuwait Univ, Fac Med, Dept Biochem, Safat 13110, Kuwait

[2] Kuwait Univ, Fac Med, Dept Pathol, Kuwait, Kuwait

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 417卷 / 01期

关键词：

glycolaldehyde; superoxide dismutase; apoptosis; breast cancer; anti-tumor activity of glycolaldehyde;

D O I：

10.1016/S0003-9861(03)00334-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activated phagocytes employ myeloperoxidase to generate glycolaldehyde, 2-hydroxypropanal, and acrolein. Because alpha-hydroxy and alpha,beta-unsaturated aldehydes are highly reactive, phagocyte-mediated formation of these products may play a role in killing bacteria and tumor cells. Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：123 / 127

页数：5

共 25 条

[1] Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein - A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation [J].