The evolution and mechanisms of nucleotide excision repair proteins

被引:54
作者
Rouillon, Christophe [1 ]
White, Malcolm F. [1 ]
机构
[1] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
Archaea; XPB; XPD; XPF; Helicase; Nuclease; DNA-BINDING-PROTEIN; XERODERMA-PIGMENTOSUM; ESCHERICHIA-COLI; CRYSTAL-STRUCTURE; ENDONUCLEASE; HELICASE; XPD; REPLICATION; RECOGNITION; NUCLEASE;
D O I
10.1016/j.resmic.2010.09.003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Nucleotide excision repair (NER) pathways remove a wide variety of bulky and helix-distorting lesions from DNA, and involve the coordinated action of damage detection, helicase and nuclease proteins. Most archaeal genomes encode eucaryal-type NER proteins, including the helicases XPB and XPD and nuclease XPF. These have been a valuable resource, yielding important mechanistic and structural insights relevant to human health. However, the nature of archaeal NER remains very uncertain. Here we review recent studies of archaeal NER proteins relevant to both eucaryal and archaeal NER systems and the evolution of repair pathways. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:19 / 26
页数:8
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