Liver fibrosis and chronic viral hepatitis

被引：48

作者：

Gutierrez-Reyes, Gabriela

Gutierrez-Ruiz, Maria Concepcion

Kershenobich, David

机构：

[1] Univ Nacl Autonoma Mexico, Dept Expt Med, Mexico City 06726, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Gen Hosp, Dept Expt Med, Mexico City 04510, DF, Mexico

[3] Univ Autonoma Metropolitana, Mexico City, DF, Mexico

来源：

ARCHIVES OF MEDICAL RESEARCH | 2007年 / 38卷 / 06期

关键词：

hepatitis B; hepatitis C; liver fibrosis; diagnosis;

D O I：

10.1016/j.arcmed.2006.10.001

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Liver fibrosis results from chronic damage to the liver in conjunction with the progressive accumulation of fibrillar extracellular matrix proteins. Fibrosis progression in patients with chronic viral hepatitis is a dynamic process where hepatic stellate cells, the most important contributor cell type, respond to a variety of host genetic factors and viral proteins. The abuse of alcohol, superimposed fatty liver disease, and age at the time of viral infection are some of the factors that accelerate liver fibrosis. Liver biopsy remains the gold standard to diagnose fibrosis and significant advances have been made to develop noninvasive markers for liver fibrosis. (C) 2007 IMSS. Published by Elsevier Inc.

引用

页码：644 / 651

页数：8

共 101 条

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