MR imaging of postischemic neuronal death in the substantia nigra and thalamus following middle cerebral artery occlusion in rats

被引：19

作者：

Abe, O

Nakane, M

Aoki, S

Hayashi, N

Masumoto, T

Kunimatsu, A

Mori, H

Tamura, A

Ohtomo, K

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Radiol, Bunkyo Ku, Tokyo 1138655, Japan

[2] Teikyo Univ, Sch Med, Dept Neurosurg, Itabashi Ku, Tokyo 1738605, Japan

来源：

NMR IN BIOMEDICINE | 2003年 / 16卷 / 03期

关键词：

postischemic neuronal death; middle cerebral artery occlusion; substantia nigra; thalamus; magnetic resonance imaging; T-2 relaxation time; apparent diffusion coefficient;

D O I：

10.1002/nbm.823

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The goal of this study was to investigate apparent diffusion coefficient (ADC) and T-2 relaxation time (T-2) in the substantia nigra and thalamus after middle cerebral artery occlusion in rats. In the substantia nigra ipsilateral to infarct, ADC was significantly lower and T-2 was significantly higher on the third and fourth days, but they did not change significantly on the first, second, eighth and 15th days. In the ipsilateral thalamus, ADC and T-2 did not change significantly between the first and fourth days, but were significantly lower on the eighth and 15th days. This combination of MR findings suggested that secondary degeneration in the thalamus was different from that in the substantia nigra. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：152 / 159

页数：8

共 30 条

[1] Temporal changes of the apparent diffusion coefficients of water and metabolites in rats with hemispheric infarction: Experimental study of transhemispheric diaschisis in the contralateral hemisphere at 7 tesla [J].