Gene dosage in the evolution and function of mammalian sex chromosomes

被引：49

作者：

Graves, JAM ^{[1
]}

Disteche, CM

Toder, R

机构：

[1] La Trobe Univ, Sch Genet & Human Variat, Dept Genet & Human Variat, Bundoora, Vic 3083, Australia

[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[3] Univ Freiburg, Dept Human Genet & Anthropol, Freiburg, Germany

来源：

CYTOGENETICS AND CELL GENETICS | 1998年 / 80卷 / 1-4期

关键词：

D O I：

10.1159/000014963

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ohno's early suggestions about the origin of sex chromosomes and the consequences of alterations of dosage of X and Y genes have provided an important framework for understanding sex chromosome organization, function and evolution. Here we review evidence that heteromorphic sex chromosomes evolved from an autosomal pair, and that one of the consequences of X-Y differentiation is the evolution of dosage compensation by X inactivation and upregulation of the active X, which in turn, has selected for a highly conserved X chromosome.

引用

页码：94 / 103

页数：10

共 63 条

[1] INACTIVATION OF THE ZFX GENE ON THE MOUSE X-CHROMOSOME [J].