IL28B Polymorphism Does Not Determine Outcomes of Hepatitis B Virus or HIV Infection

被引：99

作者：

Martin, Maureen P. ^{[2
]}

Qi, Ying ^{[2
]}

Goedert, James J. ^{[3
]}

Hussain, Shehnaz K. ^{[5
]}

Kirk, Gregory D. ^{[1
]}

Hoots, W. Keith ^{[4
]}

Buchbinder, Susan ^{[6
]}

Carrington, Mary ^{[2
]}

Thio, Chloe L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD 21205 USA

[2] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick, Frederick, MD 21701 USA

[3] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA

[4] NHLBI, Div Blood Dis & Resources, Bethesda, MD 20892 USA

[5] Univ Calif Los Angeles, Los Angeles, CA USA

[6] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 11期

基金：

美国国家卫生研究院;

关键词：

C VIRUS; INTERFERON-LAMBDA; GENETIC-VARIATION; REPLICATION; CLEARANCE; CELLS; MICE;

D O I：

10.1086/657146

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

An IL28B haplotype strongly determines the outcome of natural and interferon-alpha treated hepatitis C virus (HCV) infection. To assess whether the polymorphism marking the haplotype (rs12979860) also affects other interferon-alpha responsive chronic viral illnesses, namely hepatitis B virus (HBV) and human immunodeficiency virus (HIV) type 1 infections, we genotyped 226 individuals with HBV persistence, 384 with HBV recovery, and 2548 with or at high risk for HIV infection. The C/C genotype of rs12979860 was not associated with HBV recovery (odds ratio, 0.99), resistance to HIV infection (odds ratio, 0.97), or HIV disease progression (P>1.05). This IL28B single-nucleotide polymorphism affects the immune response to HCV but not to HBV or HIV.

引用

页码：1749 / 1753

页数：5

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