Activation and regulation of cellular eicosanoid biosynthesis

被引：45

作者：

Brock, Thomas G. ^{[1
]}

Peters-Golden, Marc ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Pulm & Crit Care Med, Hlth Syst, Ann Arbor, MI 48109 USA

来源：

THESCIENTIFICWORLDJOURNAL | 2007年 / 7卷

关键词：

eicosanoid; biosynthesis; regulation; arachidonic acid; cyclooxygenase; prostanoids; 5-lipoxygenase; leukotriene; lipoxin;

D O I：

10.1100/tsw.2007.180

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 [工学]; 0830 [环境科学与工程];

摘要：

There is a growing appreciation for the wide variety of physiological responses that are regulated by lipid messengers. One particular group of lipid messengers, the eicosanoids, plays a central role in regulating immune and inflammatory responses in a receptor-mediated fashion. These mediators are related in that they are all derived from one polyunsaturated fatty acid, arachidonic acid. However, the various eicosanoids are synthesized by a wide variety of cell types by distinct enzymatic pathways, and have diverse roles in immunity and inflammation. In this review, the major pathways involved in the synthesis of eicosanoids, as well as key points of regulation, are presented.

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收藏

页码：1273 / 1284

页数：12

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