A new and simple approach to chemical complexity. Application to the synthesis of natural products

被引：56

作者：

Barone, R ^{[1
]}

Chanon, M ^{[1
]}

机构：

[1] Fac Sci St Jerome, Lab AM3, F-13397 Marseille 20, France

来源：

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 2001年 / 41卷 / 02期

关键词：

D O I：

10.1021/ci000145p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach to describe the complexity of chemical structures is proposed. This index is simple and can be easily programmed. It derives from Whitlock's index and, despite its empirical character, provides results paralleling those obtained with the mathematical Bertz index. It has been applied to follow the strategic progress of some natural product syntheses.

引用

页码：269 / 272

页数：4

共 12 条

[1] HOLOWin: A fast way to search for tandem reactions with computer. Application to the taxane framework. [J].

Barberis, F ;

Barone, R ;

Chanon, M .

TETRAHEDRON, 1996, 52 (46) :14625-14630

[2] THE 1ST GENERAL INDEX OF MOLECULAR COMPLEXITY [J].

BERTZ, SH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (12) :3599-3601

[3] CONVERGENCE, MOLECULAR COMPLEXITY, AND SYNTHETIC ANALYSIS [J].

BERTZ, SH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (21) :5801-5803

[4]

Chanon M, 1998, SYNTHESIS-STUTTGART, P1559

[5] TOTAL SYNTHESIS OF LONGIFOLENE [J].

COREY, EJ ;

OHNO, M ;

MITRA, RB ;

VATAKENCHERRY, PA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (03) :478-&

[6] REVIEW OF RING PERCEPTION ALGORITHMS FOR CHEMICAL GRAPHS [J].

DOWNS, GM ;

GILLET, VJ ;

HOLLIDAY, JD ;

LYNCH, MF .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1989, 29 (03) :172-187

[7] COBALT WAY TO DL-ESTRONE, A HIGHLY REGIOSPECIFIC FUNCTIONALIZATION OF 2,3-BIS(TRIMETHYLSILYL)ESTRATRIEN-17-ONE [J].

FUNK, RL ;

VOLLHARDT, KPC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (01) :215-217

[8] MOLECULAR COMPLEXITY - A SIMPLIFIED FORMULA ADAPTED TO INDIVIDUAL ATOMS [J].

HENDRICKSON, JB ;

HUANG, P ;

TOCZKO, AG .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1987, 27 (02) :63-67

[9] NEW AND EFFICIENT TOTAL SYNTHESIS OF (+/)-LONGIFOLENE [J].

OPPOLZER, W ;

GODEL, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (08) :2583-2584

[10] SYNTHETIC STUDIES ON CAROTANE AND DOLASTANE TYPE TERPENES - A NEW ENTRY TO THE TOTAL SYNTHESIS OF (+/-)-DAUCENE VIA INTRAMOLECULAR [2+2] PHOTOCYCLOADDITION [J].

SETO, H ;

FUJIMOTO, Y ;

TATSUNO, T ;

YOSHIOKA, H .

SYNTHETIC COMMUNICATIONS, 1985, 15 (14) :1217-1224

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