Retinoic Acid-Inducible Gene-I-Like Receptors

被引：65

作者：

Onoguchi, Kazuhide ^{[1
]}

Yoneyama, Mitsutoshi ^{[1
]}

Fujita, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Dept Mol Genet, Sakyo Ku, Kyoto 6068507, Japan

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2011年 / 31卷 / 01期

关键词：

RNA HELICASE LGP2; DIFFERENTIATION-ASSOCIATED GENE-5; ANTIVIRAL INNATE IMMUNITY; DOUBLE-STRANDED-RNA; RIG-I; 5'-TRIPHOSPHATE RNA; VIRUS-INFECTION; CYTOSOLIC DNA; INTERFERON; RESPONSES;

D O I：

10.1089/jir.2010.0057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinoic acid-inducible gene-I (RIG-I), melanoma differentiation-associated 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2) form a family of DExD/H box RNA helicases. RIG-I-like receptors (RLRs) are expressed ubiquitously at low levels, and their expression is induced by treatment with type I interferon (IFN) or a viral infection. RLRs function as sensors for the detection of viral RNA (such as double-stranded RNA) in the cytoplasm to initiate antiviral responses by producing type I and type III IFNs. Unlike Toll-like receptors, which sense exogenous pathogen-associated molecular patterns, RLRs detect cytoplasmic viral RNA. Because RLRs are IFN-inducible viral sensors, they are critical in amplifying antiviral responses.

引用

页码：27 / 31

页数：5

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