Immunological mechanisms of vaccination

被引：750

作者：

Pulendran, Bali ^{[1
,2
]}

Ahmed, Rafi ^{[1
,3
]}

机构：

[1] Emory Univ, Emory Vaccine Ctr, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Pathol, Atlanta, GA 30322 USA

[3] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 06期

基金：

美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;

关键词：

DENDRITIC CELL SUBSETS; YELLOW-FEVER VACCINE; CD8; T-CELLS; CXC CHEMOKINE RECEPTOR-5; ANTIGEN-SPECIFIC MEMORY; VARICELLA-ZOSTER-VIRUS; INNATE IMMUNE-SYSTEM; NATURAL-KILLER-CELLS; TOLL-LIKE RECEPTORS; IN-VIVO;

D O I：

10.1038/ni.2039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccines represent one of the greatest triumphs of modern medicine. Despite the common origins of vaccinology and immunology more than 200 years ago, the two disciplines have evolved along such different trajectories that most of the highly successful vaccines have been made empirically, with little or no immunological insight. Recent advances in innate immunity have offered new insights about the mechanisms of vaccine-induced immunity and have facilitated a more rational approach to vaccine design. Here we will discuss these advances and emerging themes on the immunology of vaccination.

引用

页码：509 / 517

页数：9

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